The article highlights the urgent need for biofortification in wheat to combat “hidden hunger” caused by micronutrient deficiencies, particularly zinc, iron, selenium, and provitamin A. Wheat provides a significant portion of global caloric and protein intake, yet its micronutrient content is insufficient to meet dietary needs, especially in low-income populations. This collection of studies explores multiple approaches: genetic mapping of quantitative trait loci (QTL) for zinc and iron, agronomic biofortification methods such as foliar application and soil amendments, microbial-assisted biofortification, and breeding using genome-wide association studies and genome editing. Clinical trials demonstrate that biofortified wheat significantly increases dietary zinc intake. The overarching theme emphasizes integrating genetic, agronomic, and microbial approaches to develop nutrient-dense wheat varieties that improve global nutrition sustainably.